一群前蘇聯的極端分子搶了Ukraine北部的城市——Chernobyl，並且威脅將釋放比起第二次世界大戰原子彈百倍的更具致命死亡率、毀滅性的輻射雲朵。美軍因此而帶進一名生物機械增強的超級兵士Luc Deveraux（尚格·云顿飾）以破壞敵軍的秘密計劃。

當Deveraux逐漸往發電廠接近，他與其先前對手，復活的Andrew Scott（杜夫·朗格）及最新‘更新’的下一代萬能兵士對峙。在這一場戰斗中，Deveraux一定要竭盡所能保護地球……。

The militant Islamist Chechen Basayev abducts the children of the President and takes control of Chernobyl , threatening to unleash a radioactive cloud unless his demands are met. Luc Deveraux (Jean-Claude Van Damme), now a Universal Soldier again, joins a new team of UniSols secretly held in deep storage. Their mission: retake Chernobyl and disable explosives that will unleash radioactive clouds. Luc discovers that one of the reactivated Universal Soldiers is a clone of his old, homicidal Sergeant, Andrew Scott (Dolph Lundgren). He also must face the NGU, the next generation in the UniSol biotechnology.